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JointXL Plus vs. Doctor's Best MSM: Which Is Better for Reducing Knee Osteoarthritis Pain?

JointXL Plus and Doctor's Best MSM see which supplement offers superior relief for knee osteoarthritis pain. Learn about the key ingredients in each formula and how they target inflammation and support joint health.

By JointXL Plus Staff Updated on
JointXL Plus vs. Doctor's Best MSM JointXL Plus vs. Doctor's Best MSM

Are you struggling with persistent knee pain due to osteoarthritis? If so, you are not alone. Many people around the globe are affected by this long-term condition that can significantly limit one’s ability to move and enjoy life. This leads to pains, stiffness, and swelling of joints thus hampering the performance of various activities in daily life. It is crucial to manage knee osteoarthritis pain in order to lead an active and fulfilling life. There are several known methods of how this condition can be managed, like therapy, medications, or joint supplements. Specifically, in this article, we will examine the differences between two supplements, Joint XL Plus and Doctor’s Best MSM, to identify which product may work best in serving to reduce knee osteoarthritis pain. At the end of the article, you will know which supplement may provide you with the most benefit by helping your joint pains and overall joint health.

Knee Osteoarthritis Pain And How to Manage?

Knee Osteoarthritis Pain Knee Osteoarthritis Pain

Understanding Knee Osteoarthritis Pain

Osteoarthritis of the knee is a widespread ailment that is present in millions of people around the globe.

It is a medical condition where the cartilage in the knee joint collapses gradually and causes pain, stiffness, and swelling.

This can greatly affect day-to-day activities and diminish the quality of living for those suffering from this.

The Importance of Managing Knee Osteoarthritis Pain

Management of knee osteoarthritis is significant in providing relief to patients with a view to boosting up mobility and reducing pain and discomfort experienced in the knee joint.

Osteoarthritis cannot be cured but there are different approaches that one can take to minimize the pain and enhance the flexibility of the joint.

Treatment Options for Knee Osteoarthritis Pain


Appropriate painkiller drugs that could be obtained without prescription include acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) which are useful in managing pain that comes with knee osteoarthritis. Nonetheless, the use of NSAIDs has been reported to have severe physical impacts on the stomach and kidneys in the long run.

Physical Therapy:

There are specific physical therapy exercises and stretches that can assist improve the flexibility of the joint, and the strength of muscles adjacent to the joint, as well as decrease pain. An exercise program that is designed for a specific person may be prescribed by a physical therapist.

Weight Management:

Weight control is important in addressing pain from knee osteoarthritis because the ailment is worsened by excess weight. Being overweight means that there will be more stress on the knees adding pressure and making the pains and inflammation worse. Even small weight loss is effective in decreasing symptoms.

Joint Supplements:

Joint supplements like JointXL Plus and Doctor’s Best MSM offer to reduce joint pains and enhance joint health. These supplements include glucosamine, chondroitin, and MSM which are believed to have a positive effect on the cartilage as well as easing inflammation.

Overview Of JointXL Plus: Ingredients and Benefits

JointXL Plus Supplement Facts JointXL Plus Supplement Facts

JointXL Plus is an all–in–one joint solution that aims at combating joint pain, and inflammation and enhancing the mobility of the joints.

Due to the natural formula, the supplement helps in addressing several joint problems including inflammation, rigidity, and sensitivity.

Every capsule is designed with an appropriate composition of the necessary substances that are essential for healthy joints and mobility.

Ingredients Of JointXL Plus

Boswellia Serrata:

As an anti-inflammatory agent, Boswellia Serrata helps relieve pain and swelling associated with arthritis.


This enzyme that is present in pineapple helps to reduce inflammation and acts as a pain reliever hence promoting joint health.

According To Robert McLaughlin II, MD Bromelain, an enzyme found in pineapples, offers notable anti-inflammatory and analgesic benefits. It breaks down fibrin and reduces tissue inflammation, which is crucial for post-injury recovery. I've seen patients benefit from bromelain supplements, especially in managing postoperative swelling and pain, aligning with the research supporting its efficacy in enhancing joint health and speeding up recovery processes.


A source of organic sulfur MSM has the ability to help minimize pain in the muscle tissues and decrease metabolic stress on joints.


Beneficial for the bones and joints, glucosamine aids in the reconstruction of worn-out cartilage, which is a component of connective tissues in joint cartilage.


It also has an impact on the reduction of inflammation markers which assist in relieving osteoarthritis symptoms.

Benefits Of JointXL Plus

Benefits Of JointXL Plus Benefits Of JointXL Plus
Reduced Swelling:

JointXL Plus works to eliminate and decrease inflammation in the joints thus improving the comfort and mobility of affected joints.

Improved Flexibility:

The supplement also has the benefit of improving flexibility and joint and cartilage lubrication due to its ability to reconstruct connective tissues.

Antioxidant Support:

The formula contributes to the overall protection of the body organs and the skin through antioxidant properties.

Overview of Doctor's Best MSM: Ingredients and Benefits

Doctor's Best MSM Supplement Facts Doctor's Best MSM Supplement Facts

Doctor’s Best MSM is a dietary supplement designed to provide the body with MSM (methylsulfonylmethane) necessary for healthy joint and other organ functioning.

MSM is a safe, herbal, and natural source of sulfur that is rather important in the development of the body’s connective tissues.

Doctor’s Best joint supplement is another effective MSM health supplement in the form of a power that makes it easy to consume.

Ingredients Of Doctor's Best MSM


Doctor’s Best MSM consists only of MSM, which is a crucial component necessary for the synthesis of sulfur and the support of joint health.

Other Ingredients:

Some of the ingredients utilized in the formula include microcrystalline cellulose, stearic acid, and magnesium stearate.

Benefits Of Doctor's Best MSM

Joint Support:

It supplies the body with important nutrients that are vital to the joints and thus enhance movements, flexibility, and overall joint functions.

Minimal Ingredients:

With only MSM as the sole active ingredient, it is ideal for people with allergies and sensitivities to other compounds.

JointXL Plus vs. Doctor's Best MSM: Key Differences

Name JointXL Plus Doctor's Best MSM
JointXL Plus
Doctor's Best MSM
Rating 4.9 out of 5 3.0 out of 5
Claims JointXL Plus alleviates joint pain, reduces inflammation, and improves flexibility Doctor's Best MSM supports overall joint mobility and a normal range of motion
Ingredients Boswellia Serrata, Bromelain, MSM, Glucosamine, Methionine MSM
Form Capsule Tablet
Dose/usage 3 JointKL Plus Capsule a day before a meal 1 Tablet twice daily with food
Where To Buy Buy JointXL Plus Buy Doctor's Best MSM

How JointXL Plus Reduces Knee Osteoarthritis Pain?

JointXL Plus Review JointXL Plus Review
Anti-Inflammatory Action:

JointXL Plus has Boswellia Serrata which improves the strength of the knee joint by relieving the swelling of these joints. This was found to be effective in reducing pain in persons with knee osteoarthritis.

Cartilage Repair:

Another important ingredient of JointXL Plus is Glucosamine which can repair damaged cartilage in the knee joint. In rebuilding cartilage, it promotes the functioning of the joint as well as decreasing the amount of pain.

Improved Flexibility:

Daily intake of JointXL Plus improves the flexibility of the knee joint thus reducing the difficulty and pains in the knee joint among those with osteoarthritis knee diseases.

Antioxidant Support:

JointXL Plus comprises ingredients that have unique antioxidant effects and improve the symptoms associated with oxidative stress on the knee joints. This in turn helps to relieve pain and maintain proper joint function.

The Role of Doctor's Best MSM in Alleviating Knee Pain and Stiffness

Doctor's Best MSM Review Doctor's Best MSM Review
Sulfur for Joint Health:

MSM, or Methylsulfonylmethane, available in Doctor’s Best MSM, is a compound that contributes sulfur to the body and is vital for the support of healthy knee connective tissues.

Reduces Inflammation:

MSM has anti-inflammatory action and thus has the potential to reduce swelling and inflammation in the knee joints. This consequently reduces pain and stiffness because human joints are designed to move in circles and not flex or extend.

Supports Tissue Repair:

MSM has been known to enhance the synthesis of collagen in the joints and therefore helps in the repair of the cartilage in knees. This enhances the process of healing and the general health of the affected joints.

Both JointXL Plus and Doctor's Best MSM offer unique benefits for alleviating knee osteoarthritis pain, allowing individuals to choose the option that best suits their lifestyle and health goals.

User Reviews and Testimonials of JointXL Plus vs. Doctor's Best MSM

JointXL Plus customer reviews

Before discovering JointXL Plus, my daily jogs were becoming a painful ordeal due to my aching knees and ankles. I stumbled upon JointXL Plus when searching for a natural solution that wouldn't just mask the pain but help address the root causes. I started taking it six months ago, and it's been a part of my daily regimen ever since. The difference it has made is night and day—I recover quicker from workouts, and the morning stiffness has greatly diminished. Anytime I skip a few days, I immediately feel the difference in my joints. JointXL Plus has been an incredible find for maintaining my active lifestyle! Michael T.
Carol is a spry 69-year-old from Florida who has always embraced an active lifestyle, from yoga to cycling. When joint pain in her wrists and knees began to interfere with her activities, Carol felt her quality of life might be permanently diminished. After trying several supplements with little success, she tried JointXL Plus. Carol was particularly drawn to its comprehensive ingredient list that includes not only Glucosamine and Chondroitin but also powerful natural additives like MSM and Turmeric. She'll confidently tell you that JointXL Plus works wonders. Carol learned the importance of regular intake the hard way—she once stopped for a month and the pain returned with a vengeance. Now, she never misses a dose and enjoys her activities pain-free, recommending JointXL Plus to anyone wanting to stay active and pain-free in their later years. Carol Stevens.

Doctor's Best MSM customer reviews

Product is great but no replacement if damaged. I have used this before and I love it. While i didnt take it long enough to see blatantly noticeable results, i do feel as if it helped with my joints feeling a lot less sore and stiff after work, my hair grew longer in a shorter period of time than normal, and i had some very entertaining dreams. However, if you are wary of your product coming damaged, you may need to look into another brand. I ordered 2 and one of them came with a silver seal and the other had a cracked lid, no silver seal, just a paper seal which was also broken open. I tried to reach out for a replacement because its not safe to take now, but they dont do replacements or returns for this item. Just a heads up. Buy at your own risk. Melissa dale
Drink water while on this The most important thing I would say is drink, drink, drink your water!! While taking this it makes you severely dehydrated and if you don’t drink your water while you take this you will suffer!! You will break out, have major headaches and it won’t be a fun experience. So, make sure you drink your water while on this supplement. Peter kane

JointXL Plus joint supplement is highly rated by its users because of its ability to help in the reduction of joint pains and enable persons to engage in an active lifestyle.

Michael T. and Carol Stevens highlight the supplement's positive effects on their joint health and recovery. Their journey itself is enough to how JointXL Plus usage helped to stay active and alleviate previous pain.

On the other hand, Doctor’s Best MSM produces service and mixed reviews from its users. Melissa Dale finds it helpful for arthritis and hair but has many issues with quality and safety as packages are damaged with no replacement/return policy.

Peter Kane stresses the necessity of proper fluid intake during supplement consumption also, because, if the water intake is inadequate, it can lead to severe dehydration and other unfavorable outcomes.

Effectiveness of JointXL Plus and Doctor's Best MSM

JointXL Plus Effectiveness

JointXL Plus Effectiveness JointXL Plus Effectiveness

Many people have described JointXL Plus as an effective supplement that can cure joint pain and enhance joint health.

With its all-natural composition, it addresses inflammation – a primary reason behind joint pain – and aims to minimize soreness and rigidity.

Some of the customers have even noted that the JointXL Plus has helped them to reduce the pain that is associated with arthritis and has increased flexibility when used consistently.

The ingredients used in this supplement such as Boswellia Serrata, Bromelain, MSM, Glucosamine, and Methionine are effective in supporting joint function and nourishing damaged cartilage.

The effectiveness of JointXL Plus has been proven by many users who noticed that the supplement helps to reduce swelling, increase flexibility, and support antioxidants, promoting healthy joint function.

Doctor's Best MSM Effectiveness

Doctor's Best MSM Effectiveness Doctor's Best MSM Effectiveness

Doctor’s Best MSM is a dietary supplement that helps the body obtain MSM, which is essential for joint health.

While sulfur is vital for collagen synthesis needed in connective tissues, Doctor’s Best MSM only contains this single element.

This product has been noted to successfully reduce swelling and inflammation while increasing flexibility in the joints.

However, some concerns have been raised regarding the taste of the product as well as its ability to dissolve well.

Nonetheless, Doctor’s Best MSM continues to be a go-to supplement for those who are looking for a basic and reasonably priced solution for joint health concerns.

Side Effects of JointXL Plus and Doctor's Best MSM

JointXL Plus Side Effects

Mild Digestive Issues:

Some customers may report some digestive problems like bloating or gas when they use JointXL Plus. This is usually exhibited during the initial few weeks of using the supplement, especially if the body is not used to the supplement.

Allergic Reactions:

Although rare, there are people who may be sensitive to some of the compounds contained in JointXL Plus and develop itching, rash, or swelling. Thus, it is essential to stop using the product and seek medical advice in case of allergic symptoms.

Doctor's Best MSM Side Effects


Some people may experience dehydration if they are not consuming enough fluids. This can bring about symptoms including headache or dry mouth. However, those taking this supplement should ensure they take enough fluids during the course of the day.

Gastrointestinal Discomfort:

Some of the possible side effects of Doctor’s Best MSM, might include nausea or upset stomach. Consuming the supplement with meals or incorporating it in beverages can further decrease these symptoms.

Sulfur Taste:

Some individuals may consider Doctor’s Best MSM to have an offending taste because of its sulfur content. It can especially be mixed with flavored beverages to help eliminate the taste of the primary ingredient.

Both JointXL Plus and Doctor's Best MSM are generally well-tolerated supplements with minimal side effects.

But it is always wise to keep an eye on the possible reactions and in any case of doubt, one should seek the assistance of a healthcare professional.

Always start with a low dosage build-up to the intended dose, and adhere to the dosage guidelines recommended.

Remember that every person is unique and might have different reactions to supplements, thus if you encounter any side effects stop using the supplements.

Knowing the possible side effects will help you decide the best joint supplement that you should take.

Cost and Value: JointXL Plus vs. Doctor's Best MSM

JointXL Plus

  • Cost: JointXL Plus is priced at $54 for one bottle, $108 for three bottles, and $180 for six bottles.
  • Accessibility: JointXL Plus is readily available for purchase online on the official website, offering convenience and accessibility to users.
JointXL Plus Cost and Value JointXL Plus Cost and Value

Doctor's Best MSM

  • Cost: Doctor's Best MSM is priced affordably, typically costing around $21.40 per bottle.
  • Accessibility: Doctor's Best MSM is widely available in stores and online, making it easily accessible to consumers.

In terms of cost and value for money, both JointXL Plus and Doctor's Best MSM offer affordable options for individuals seeking joint support.

However, JointXL Plus best supplement for joint health stands out for its premium blend of ingredients and proven effectiveness in reducing joint pain and inflammation.

While Doctor's Best MSM may be a suitable option for those on a tight budget, individuals looking for comprehensive joint support may find greater value in JointXL Plus.

Conclusion: Choosing the Best Supplement for Knee Osteoarthritis Pain

JointXL Plus and Doctor’s Best MSM comprise healthy supplements that will assist people who have different needs in leading a healthy lifestyle. Thus, Joint XL Plus is an all-in-one formula with the capacity to fight against arthritis joint pain, inflammation, and stiffness.

By incorporating selected components in the formulation of this supplement, it seeks to address different factors that may affect the joints including cartilage regeneration, inflammation reduction, and promotion of antioxidant function.

On the other hand, Doctor’s Best joint health supplement offers a more straightforward approach since its strategy is based on the numerous advantages of MSM.

However, this product is affordable and easily accessible, it lacks the comprehensive ingredient profile found in JointXL Plus. Similarly, users have reported concerns that affect the taste, dehydrative state, and quality of the packaging.

For those seeking a comprehensive supplement to alleviate knee osteoarthritis pain, the JointXL Plus joint health supplement is the most ideal product.

The unique composition of the supplement is aimed at not only relieving joint pain and inflammation but also at maintaining the joints’ proper functioning and flexibility in the long term.

While Doctor's Best MSM may be suitable for individuals on a budget, those looking for a more robust and effective solution may find greater satisfaction with JointXL Plus.

Therefore, while there are so many supplements in the market, the most appropriate supplement will depend on the health status of the user as well as their lifestyle, but based on the studies done above it can be concluded that JointXL Plus may offer a better solution to knee osteoarthritis pain in many way s than other supplements.


What are the main ingredients in JointXL Plus?

JointXL Plus includes Boswellia Serrata, Bromelain, MSM, Glucosamine, and Methionine.

How should I take JointXL Plus?

Take 3 pills a day before a meal for best results.

Does JointXL Plus help reduce inflammation?

Yes, it contains anti-inflammatory agents like Boswellia Serrata to reduce joint swelling.

Can JointXL Plus help with cartilage repair?

Yes, Glucosamine in JointXL Plus aids in repairing worn-out cartilage.

What are the common side effects of JointXL Plus?

Some users report mild digestive issues and rare allergic reactions.

What is the primary ingredient in Doctor's Best MSM?

The primary ingredient is MSM (Methylsulfonylmethane).

How should I take Doctor's Best MSM?

Take 1 tablet twice daily with food, or as recommended by a nutritionally informed physician.

Does Doctor's Best MSM help with joint flexibility?

Yes, it supports overall joint mobility and normal range of motion.

Are there any side effects to Doctor's Best MSM?

Some users may experience dehydration and gastrointestinal discomfort.


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